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Hao Wu, Li-Li Zhang, Zhi-Qing Tian, Dr. Yao-Dong Huang and Prof. Yong-Mei Wang Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael–Cyclization Reaction Chemistry - A European Journal 19

Version of Record online: 18 DEC 2012 | DOI: 10.1002/chem.201203221

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Cascade to complexity: Bispirooxindole derivatives containing three stereocenters, including two spiro quarternary centers, were synthesized in a high-yielding, atypically rapid, and stereocontrolled cascade Michael–cyclization reaction between methyleneindolinones and isothiocyanato oxindoles catalyzed by a bi- or multifunctional organocatalyst (see scheme).

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