E-mail

E-mail a Wiley Online Library Link

Dr. Arash Ghaderi, Dr. Takanori Iwasaki, Asuka Fukuoka, Prof. Dr. Jun Terao and Prof. Dr. Nobuaki Kambe Nickel-Catalyzed Coupling of Thiomethyl-Substituted 1,3-Benzothiazoles with Secondary Alkyl Grignard Reagents Chemistry - A European Journal 19

Article first published online: 25 JAN 2013 | DOI: 10.1002/chem.201203413

Thumbnail image of graphical abstract

Synthetic methods: The Ni-catalyzed alkylation of 2-(methylthio)benzothiazoles through C[BOND]S bond cleavage is reported. Reactions with various secondary alkyl nucleophiles proceeded efficiently in the presence of 1,3-butadiene as an additive. This reaction was proposed to proceed by σ-bond metathesis between the thioether and a bis(π-allyl)nickel complex or by an addition/elimination mechanism involving the C[DOUBLE BOND]N double bond of the benzothiazoles (see scheme).

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH