Arnaud Chevalier, Dr. Cédrik Massif, Prof. Pierre-Yves Renard and Dr. Anthony Romieu Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes Chemistry - A European Journal 19
Black is beautiful! The azo-coupling reaction between Methylene Violet 3RAX and functionalized tertiary anilines has been revisited to obtain a series of novel BHQ-3 dyes with various reactive handles (see figure). The bioconjugation ability of such modified dark quenchers was illustrated by the preparation of urokinase-sensitive fluorogenic probes in good yields.
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