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Arnaud Chevalier, Dr. Cédrik Massif, Prof. Pierre-Yves Renard and Dr. Anthony Romieu Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes Chemistry - A European Journal 19

Version of Record online: 18 DEC 2012 | DOI: 10.1002/chem.201203427

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Black is beautiful! The azo-coupling reaction between Methylene Violet 3RAX and functionalized tertiary anilines has been revisited to obtain a series of novel BHQ-3 dyes with various reactive handles (see figure). The bioconjugation ability of such modified dark quenchers was illustrated by the preparation of urokinase-sensitive fluorogenic probes in good yields.

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