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Anne-Catherine Bédard and Prof. Dr. Shawn K. Collins Exploiting Aggregation To Achieve Phase Separation in Macrocyclization Chemistry - A European Journal 19

Article first published online: 28 DEC 2012 | DOI: 10.1002/chem.201203433

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PEGing out macrocycles: Macrocyclization through Glaser–Hay coupling can be conducted at high concentrations by exploiting solvent mixtures containing poly(ethylene glycol)400 (PEG400)/MeOH (see scheme). Surface tension measurements, UV spectroscopy, and chemical tagging demonstrate the dependence of the yield and selectivity on the aggregation of PEG400 and its ability to preferentially solubilize organic substrates, resulting in a phase separation from the catalyst system.

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