E-mail a Wiley Online Library Link

Anne-Catherine Bédard and Prof. Dr. Shawn K. Collins Exploiting Aggregation To Achieve Phase Separation in Macrocyclization Chemistry - A European Journal 19

Article first published online: 28 DEC 2012 | DOI: 10.1002/chem.201203433

Thumbnail image of graphical abstract

PEGing out macrocycles: Macrocyclization through Glaser–Hay coupling can be conducted at high concentrations by exploiting solvent mixtures containing poly(ethylene glycol)400 (PEG400)/MeOH (see scheme). Surface tension measurements, UV spectroscopy, and chemical tagging demonstrate the dependence of the yield and selectivity on the aggregation of PEG400 and its ability to preferentially solubilize organic substrates, resulting in a phase separation from the catalyst system.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.