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Dr. Dongmei Yang, Dr. Yunlu Dai, Dr. Pingan Ma, Dr. Xiaojiao Kang, Dr. Ziyong Cheng, Dr. Chunxia Li and Prof. Jun Lin One-Step Synthesis of Small-Sized and Water-Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery Chemistry - A European Journal 19

Article first published online: 7 JAN 2013 | DOI: 10.1002/chem.201203634

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RE ready to deliver: Small-sized and water-soluble NaREF4 (rare earth (RE)=Nd[BOND]Lu, Y) nanoparticles (NPs) were synthesized by an oil/water two-phase approach (see scheme). Hollow-structured NPs can be fabricated in situ by electron-beam lithography on solid NPs. The as-prepared hollow-structured NaLuF4:Yb3+, Er3+ can be used as an anticancer drug carrier to investigate their cytotoxic effect against HeLa cells. Furthermore, these NaLuF4:Yb3+, Er3+ NPs show bright-red emission, which can be used for upconversion cell imaging.

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