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Dr. Hui Cai, Zhan-Yi Sun, Zhi-Hua Huang, Lei Shi, Prof. Dr. Yu-Fen Zhao, Prof. Dr. Horst Kunz and Prof. Dr. Yan-Mei Li Fully Synthetic Self-Adjuvanting Thioether-Conjugated Glycopeptide[BOND]Lipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells Chemistry - A European Journal 19

Article first published online: 23 DEC 2012 | DOI: 10.1002/chem.201203709

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You do it to yourself: Self-adjuvanting vaccines with a tumor-associated MUC1 glycopeptide and the TLR2 ligand lipopeptide Pam3CSK4 were synthesized. Three-component vaccines induced strong antitumor immune responses that induced tumor-cell death (see scheme).

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