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Jagoda Sloniec, Matthias Schnurr, Dr. Christopher Witte, Dr. Ute Resch-Genger, Dr. Leif Schröder and Dr. Andreas Hennig Biomembrane Interactions of Functionalized Cryptophane-A: Combined Fluorescence and 129Xe NMR Studies of a Bimodal Contrast Agent Chemistry - A European Journal 19

Version of Record online: 14 JAN 2013 | DOI: 10.1002/chem.201203773

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Illuminating membranes: New bimodal contrast agents were synthesized and their interactions with different biomembrane models were investigated by a newly developed method based on fluorescence resonance energy transfer (FRET) and by hyperpolarized 129Xe NMR spectroscopy (Hyper-CEST; see figure). This combined study paves the way for their use as potential biomarkers for membrane fluidity and for more detailed and quantitative interpretation of Hyper-CEST spectra.

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