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Dr. Marco Bartoloni, Dr. Blanca E. Domínguez, Dr. Elisa Dragoni, Dr. Barbara Richichi, Dr. Marco Fragai, Dr. Sabine André, Prof. Hans-Joachim Gabius, Dr. Ana Ardá, Prof. Claudio Luchinat, Prof. Jesús Jiménez-Barbero and Prof. Cristina Nativi Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins Chemistry - A European Journal 19

Version of Record online: 27 DEC 2012 | DOI: 10.1002/chem.201203794

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A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.

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