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Prof. Dr. Hiroshi Tanaka, Ryota Takeuchi, Prof. Dr. Mitsuru Jimbo, Nami Kuniya and Prof. Dr. Takashi Takahashi Synthesis and Biological Evaluation of the Forssman Antigen Pentasaccharide and Derivatives by a One-Pot Glycosylation Procedure Chemistry - A European Journal 19

Article first published online: 16 JAN 2013 | DOI: 10.1002/chem.201203865

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Bound to change: The synthesis of the Forssman antigen pentasaccharides based on two one-pot two-step glycosylations and polymer-assisted deprotection is described. The synthetic oligosaccharides bind to the lectin SLL-2 and inhibit the morphological changes of Symbiodinium by SLL-2. In addition, the Forssman antigen pentasaccharides were found to directly promote the morphological change in Symbiodinium (see figure).

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