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Viviana Valerio, Desislava Petkova, Claire Madelaine and Dr. Nuno Maulide Direct Room-Temperature Lactonisation of Alcohols and Ethers onto Amides: An “Amide Strategy” for Synthesis Chemistry - A European Journal 19

Article first published online: 10 JAN 2013 | DOI: 10.1002/chem.201203906

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Last-minute deal: A direct lactonisation of ethers and alcohols onto amides that proceeds at room temperature under mild conditions is reported (see scheme). This allows the effective saving of up to two unproductive, sequential deprotection operations in synthetic sequences. Mechanistic studies are described, and a new “amide strategy” that exploits the dual robustness/late-stage selective activation properties of this functional group is outlined.

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