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Giulia Boscutti, Dr. Luciano Marchiò, Dr. Luca Ronconi  and Prof. Dolores Fregona Insights into the Reactivity of Gold–Dithiocarbamato Anticancer Agents toward Model Biomolecules by Using Multinuclear NMR Spectroscopy Chemistry - A European Journal 19

Article first published online: 3 SEP 2013 | DOI: 10.1002/chem.201302550

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To react or not to react? Model nitrogen- and sulfur-donor compounds can be treated with a representative gold(III)–dithiocarbamato anticancer agent to evaluate potential reactivity of such anticancer agents toward biomolecules (see figure). Detailed NMR studies show that the interaction with physiologically relevant species can lead to unexpected reaction pathways that may contribute to the novel mechanisms of cytotoxicity observed for this class of complexes.

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