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Ramanathan Vaidyanathan, Dr. Sakandar Rauf, Dr. Eloïse Dray, Dr. Muhammad J. A. Shiddiky and Prof. Matt Trau Alternating Current Electrohydrodynamics Induced Nanoshearing and Fluid Micromixing for Specific Capture of Cancer Cells Chemistry - A European Journal 20

Version of Record online: 23 FEB 2014 | DOI: 10.1002/chem.201304590

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Nanoshearing for cell capture: Tuneable nanoshearing offers a unique capability to preferentially select strongly bound cells over weakly (nonspecifically) bound cells which adhere to the surface. The tuneable nature of this force (by externally tuning the ac field) facilitates an increase in the number of sensor–target collisions and also the ability to shear away nonspecifically bound cellular species (see figure).

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