Dr. Caroline Clavel, Dr. Camille Romuald, Emile Brabet and Dr. Frédéric Coutrot Cover Picture: A pH-Sensitive Lasso-Based Rotaxane Molecular Switch (Chem. Eur. J. 9/2013) Chemistry - A European Journal 19
Wanted! A new lasso molecular shuttle was synthesized by a self-entanglement strategy. In their Full Paper on page 2982 ff., F. Coutrot et al. describe the efficient preparation of a new lasso molecular switch containing an anilinium template. Trapping of the BMP25C8 macrocycle was achieved by benzylation of the triazole moiety and allowed the isolation of a bi-stable lasso molecular switch, in which benzyltriazolium acts as a gate and a molecular station at the same time. Variation of pH triggered the tightening and loosening of the lasso.
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