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Thomas Dreher, Ute Husemann, Christian Zahnow, Davy de Wilde, Dr. Thorsten Adams and Dr. Gerhard Greller High Cell Density Escherichia coli Cultivation in Different Single-Use Bioreactor Systems Chemie Ingenieur Technik 85

Version of Record online: 2 NOV 2012 | DOI: 10.1002/cite.201200122

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Single-use bioreactors are established for cell culture processes and offer also advantages for microbial fermentations. Due to limitations in the oxygen transfer rate reports of microbial fermentations are rarely found. This study shows high cell density Escherichia coli fermentations in different single-use bioreactors, where the achieved cell densities are comparable to processes in stainless steel fermenters.

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