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Dr. Stefan Junne, Thomas Solymosi, Dr. Nico Oosterhuis and Prof. Peter Neubauer Cultivation of Cells and Microorganisms in Wave-Mixed Disposable Bag Bioreactors at Different Scales Chemie Ingenieur Technik 85

Version of Record online: 13 DEC 2012 | DOI: 10.1002/cite.201200149

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Wave-mixed bioreactors are characterized by low shear forces while gas exchange is realized through the large gas-liquid interface. This article describes applications of wave-mixed systems, current developments and as example the scale-up of an Escherichia coli fed-batch cultivation from the 12-L to 120-L scale in a disposable bioreactor.

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