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Weijun Zhu, Xingchao Tu, Hui Feng, Mansu Tu, Bo Jiang, Feiyue Wu and Shujiang Tu Dimedone-catalyzed Addition of Amines into Cyano Group: Facile Synthesis of Thiazol-2-yl Substituted E-Acrylonitriles Chinese Journal of Chemistry 30

Version of Record online: 7 MAY 2012 | DOI: 10.1002/cjoc.201100719

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An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of α-thiocyanate ketones with malononitrile and amines. The α-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives.

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