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Xiaolei Zhu, Fu Wang, Hui Li, Wenchao Yang, Qiong Chen and Guangfu Yang Design, Synthesis, and Bioevaluation of Novel Strobilurin Derivatives Chinese Journal of Chemistry 30

Version of Record online: 25 SEP 2012 | DOI: 10.1002/cjoc.201200607

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Strobilurins are one of the greatest discoveries in controlling agricultural fungus, due to the novel action mode, wide fungicidal spectrum, lower toxicity against mammalian cells, and environmentally benign characteristics. To discover new strobilurin analogues with higher fungicidal activity, a structural modification of compound 1 was carried out by the strategy of bioisosterism and evolutionally yielded a series of benzophenone derivatives 2a2j, among which compound 2j with a Ki value of 1.89 nmol/L was identified as the most promising inhibitor of porcine cytochrome bc1 complex.

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