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Chen Zhang, Hongrui Liu, Qing Yang, Jun Chang and Xun Sun Synthesis and Cytotoxic Evaluation of Novel Platinum(II) Complexes with C2-Asymmetric and C2-Symmetric Chiral Vicinal Diamines Chinese Journal of Chemistry 31

Version of Record online: 8 JAN 2013 | DOI: 10.1002/cjoc.201201168

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A series of new platinum(II) complexes with C2-asymmetric and C2-symmetric 1,2-diamines were designed and synthesized by convenient methods, involving samarium diiodide induced reductive coupling as the key step. The cytotoxicity of these analogs against four leukemia and three solid cancer cell lines was evaluated and the preliminary structure-activity relationship is also discussed. Flow cytometry data indicated that (R,R)-11a could obviously arrest leukemia K562 cells in G2/M phases.

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