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Allan J. Goodman, Bertrand Le Bourdonnec and Roland E. Dolle Mu Opioid Receptor Antagonists: Recent Developments ChemMedChem 2

Version of Record online: 8 OCT 2007 | DOI: 10.1002/cmdc.200700143

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Modifying morphine. There has been an extensive amount of research performed during the last ten years on mu opioid receptor antagonists. The positive clinical data generated with N-methylnaltrexone and alvimopan has greatly contributed to a renewed interest in this field. In this article we review various chemical classes of mu opioid receptor antagonists and the clinical applications for this class of agents.

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