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Xiaohui Wang, Jinsong Ren and Xiaogang Qu Targeted RNA Interference of Cyclin A2 Mediated by Functionalized Single-Walled Carbon Nanotubes Induces Proliferation Arrest and Apoptosis in Chronic Myelogenous Leukemia K562 Cells ChemMedChem 3

Article first published online: 19 FEB 2008 | DOI: 10.1002/cmdc.200700329

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Carbon-nanotube vectors. Cyclin A2 plays critical role in DNA replication, transcription, and cell cycle regulation. SWNTs can facilitate the coupling of siRNA specifically targeting human cyclin A2 in chronic myelogenous leukemia K562 cells. Depletion of cyclin A2 in this manner inhibits cell proliferation and promotes apoptosis demonstrating that cyclin A2 can serve as a novel therapeutic target.

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