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Lech-Gustav Milroy, Giovanna Zinzalla, François Loiseau, Zizheng Qian, Giuseppe Prencipe, Chris Pepper, Chris Fegan and Steven V. Ley Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia ChemMedChem 3

Article first published online: 21 NOV 2008 | DOI: 10.1002/cmdc.200800265

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The guiding principle of natural products is applied with success to the rapid identification of a new series of small molecules with activity against chronic lymphocytic leukaemia. These compounds are shown to induce apoptosis via a classical intrinsic drug-induced pathway with superior activity to market leader chemotherapeutics in similar screens.

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