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Jeremy L. Yap, Dr. Shilpa Worlikar, Prof. Dr. Alexander D. MacKerell Jr., Prof. Dr. Paul Shapiro and Prof. Dr. Steven Fletcher Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics ChemMedChem 6

Article first published online: 25 NOV 2010 | DOI: 10.1002/cmdc.201000354

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David and Goliath: Small-molecule inhibitors of the ERK signaling pathway (shown) and their potential as novel antitumor agents are discussed in detail within this Minireview. Specifically, the direct and indirect inhibition of ERK through ATP-competitive and non-ATP-competitive modes of action is highlighted.

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