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Dr. Max Keller, Prof. Dr. Günther Bernhardt and Prof. Dr. Armin Buschauer [3H]UR-MK136: A Highly Potent and Selective Radioligand for Neuropeptide Y Y1 Receptors ChemMedChem 6

Version of Record online: 5 JUL 2011 | DOI: 10.1002/cmdc.201100197

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Imaging the brain: Attachment of a [2,3-3H]propionyl entity through an aminobutylcarbamoyl linker to the guanidine group of an argininamide-type neuropeptide Y (NPY) Y1 receptor (Y1R) antagonist affords a stable, highly potent (Kd=2.0 nM, SK-N-MC cells) and selective Y1R radioligand.

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