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Yanyan Sun, Prof. Shaohua Gou, Fei Liu, Dr. Runting Yin and Dr. Lei Fang Synthesis, in vitro Cytotoxicity, and Interaction with DNA of Platinum(II) Complexes with N-Monocycloalkyl Derivatives of 1R,2R-Diaminocyclohexane as Carrier Ligands ChemMedChem 7

Version of Record online: 13 JAN 2012 | DOI: 10.1002/cmdc.201100467

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Platinum(II) complexes: Oxaliplatin derivatives, especially 1 f and 2 f, show similar or superior cytotoxicity to oxaliplatin. The apoptotic mechanism of complex 2 f and its ability to cause S-phase cell-cycle arrest were determined by flow cytometry. This compound has the capacity to distort DNA through a binding mode distinct from that of oxaliplatin.

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