E-mail a Wiley Online Library Link

Dr. Yi-Yu Ke, Dr. Hui-Yi Shiao, Dr. Yung Chang Hsu, Dr. Chang-Ying Chu, Dr. Wen-Chieh Wang, Yen-Chun Lee, Dr. Wen-Hsing Lin, Chun-Hwa Chen, Dr. John T. A. Hsu, Chun-Wei Chang, Dr. Cheng-Wei Lin, Dr. Teng-Kuang Yeh, Dr. Yu-Sheng Chao, Dr. Mohane Selvaraj Coumar and Dr. Hsing-Pang Hsieh 3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor ChemMedChem 8

Version of Record online: 22 NOV 2012 | DOI: 10.1002/cmdc.201200464

Thumbnail image of graphical abstract

Amazing Aurora displays: Through insight obtained from 3D-QSAR modeling of pyrazoles 119 and furanopyrimdines 2066 as Aurora kinase inhibitors, a potent quinazoline inhibitor was designed and synthesized. In vitro and in vivo experiments revealed that quinazoline 67 has the potential for further development.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field