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Dr. Yi-Yu Ke, Dr. Hui-Yi Shiao, Dr. Yung Chang Hsu, Dr. Chang-Ying Chu, Dr. Wen-Chieh Wang, Yen-Chun Lee, Dr. Wen-Hsing Lin, Chun-Hwa Chen, Dr. John T. A. Hsu, Chun-Wei Chang, Dr. Cheng-Wei Lin, Dr. Teng-Kuang Yeh, Dr. Yu-Sheng Chao, Dr. Mohane Selvaraj Coumar and Dr. Hsing-Pang Hsieh 3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor ChemMedChem 8

Version of Record online: 22 NOV 2012 | DOI: 10.1002/cmdc.201200464

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Amazing Aurora displays: Through insight obtained from 3D-QSAR modeling of pyrazoles 119 and furanopyrimdines 2066 as Aurora kinase inhibitors, a potent quinazoline inhibitor was designed and synthesized. In vitro and in vivo experiments revealed that quinazoline 67 has the potential for further development.

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