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Munmun Maiti, Leentje Persoons, Prof. Graciela Andrei, Prof. Robert Snoeck, Prof. Jan Balzarini and Prof. Piet Herdewijn Synthesis and Anti-herpetic Activity of Phosphoramidate ProTides ChemMedChem 8

Article first published online: 18 APR 2013 | DOI: 10.1002/cmdc.201300035

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Key to membrane permeability: The introduction of the pivaloyloxymethyl (POM) moiety as a carboxyl protecting group has shown promise in the design of antiviral phosphoramidate prodrugs for the intracellular delivery of nucleoside monophosphates. Antiviral data also support the substitution of a primary amine with a secondary amine in the intracellular delivery of ProTide analogues.

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