Estel.la Buscató, Dominik Büttner, Astrid Brüggerhoff, Franca-Maria Klingler, Julia Weber, Bastian Scholz, Dr. Aleksandra Živković, Prof. Dr. Rolf Marschalek, Prof. Dr. Holger Stark, Prof. Dr. Dieter Steinhilber, Prof. Dr. Helge B. Bode and Prof. Dr. Ewgenij Proschak From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties ChemMedChem 8
Article first published online: 17 APR 2013 | DOI: 10.1002/cmdc.201300057
Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.
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