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Jiamin Gu, Upendra Rao Anumala, Dr. Roland Heyny-von Haußen, Jana Hölzer, Valérie Goetschy-Meyer, Dr. Gerhard Mall, Prof. Dr. Ingrid Hilger, Dr. Christian Czech and Prof. Dr. Boris Schmidt Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer’s Disease Brain and Olfactory Epithelium ChemMedChem 8

Article first published online: 16 APR 2013 | DOI: 10.1002/cmdc.201300090

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Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.

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