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Dr. Daniela Rossi, Dr. Alice Pedrali, Dr. Raffaella Gaggeri, Dr. Annamaria Marra, Dr. Luca Pignataro, Dr. Erik Laurini, Dr. Valentina Dal Col, Prof. Maurizio Fermeglia, Prof. Sabrina Pricl, Dr. Dirk Schepmann, Prof. Bernhard Wünsch, Dr. Marco Peviani, Dr. Daniela Curti and Prof. Simona Collina Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC-33 Compounds: Promising Neuroprotective Agents Acting as σ1 Receptor Agonists ChemMedChem 8

Version of Record online: 5 JUL 2013 | DOI: 10.1002/cmdc.201300218

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A tale of two enantiomers: (S)- and (R)-RC-33, recently identified σ1 receptor agonists, were thoroughly investigated. (R)-RC-33 emerged as the optimal candidate for in vivo investigations, being a potent and selective σ1 agonist with higher in vitro hepatic metabolic stability than (S)-RC-33.

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