Dr. Dounia El Arfaoui, Dymytrii Listunov, Isabelle Fabing, Mohamed Oukessou, Céline Frongia, Dr. Valérie Lobjois, Arnaud Samson, Dr. Frédéric Ausseil, Prof. Abdeslem Ben-Tama, Prof. El Mestafa El Hadrami, Prof. Remi Chauvin and Dr. Yves Génisson Identification of Chiral Alkenyl- and Alkynylcarbinols as Pharmacophores for Potent Cytotoxicity ChemMedChem 8
Article first published online: 6 SEP 2013 | DOI: 10.1002/cmdc.201300230
Illumination by acetylene: Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring (S,E)-icos-4-en-1-yn-3-ol allowed the discovery of a series of 3R-like 1,4-di-unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.
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