Prof. Dr. Weiping Liu, Dr. Qingsong Ye, Dr. Jing Jiang, Prof. Dr. Liguang Lou, Dr. Yongping Xu, Dr. Chengying Xie and Prof. Dr. Mingjin Xie cis-[PtII(1R,2R-DACH)(3-acetoxy-1,1-cyclobutanedicarboxylato)], a Water-Soluble, Oxalate-Free and Stable Analogue of Oxaliplatin: Synthesis, Characterization, and Biological Evaluations ChemMedChem 8
Version of Record online: 3 JUL 2013 | DOI: 10.1002/cmdc.201300249
Strong, like ox! A new oxaliplatin derivative that features 3-acetoxy-1,1-cyclobutanedicarboxylate as the leaving group has good aqueous solubility and stability. It exhibits higher antitumor activity and greater tolerability than oxaliplatin.
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