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Dr. Michela Rosini, Dr. Elena Simoni, Dr. Manuela Bartolini, Dr. Elena Soriano, Prof. José Marco-Contelles, Prof. Vincenza Andrisano, Dr. Barbara Monti, Dr. Manfred Windisch, Dr. Birgit Hutter-Paier, Dr. David W. McClymont, Dr. Ian R. Mellor and Prof. Maria Laura Bolognesi The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon ChemMedChem 8

Article first published online: 3 JUL 2013 | DOI: 10.1002/cmdc.201300263

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Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions.

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