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Subhendu Bhowmik, Shruti Khanna, Dr. Kumkum Srivastava, Mohammad Hasanain, Dr. Jayanta Sarkar, Prof. Sandeep Verma and Dr. Sanjay Batra An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and their Evaluation as Inhibitors of Insulin Aggregation ChemMedChem 8

Article first published online: 5 SEP 2013 | DOI: 10.1002/cmdc.201300302

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A controlled cascade: A divergent, diastereoselective and efficient one-pot synthesis of allocolchicinoids via a cascade Suzuki–Michael addition–Carbocyclization sequence is described. The utility of the compounds as possible inhibitors of insulin aggregation is also presented.

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