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Dr. Grégory Coué, Dr. Iris Hermanns, Dr. Ronald E. Unger, Prof. C. James Kirkpatrick and Prof. Johan F. J. Engbersen Development and in vitro Evaluation of Antigen-Loaded Poly(amidoamine) Nanoparticles for Respiratory Epithelium Applications ChemMedChem 8

Article first published online: 5 SEP 2013 | DOI: 10.1002/cmdc.201300307

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A nose for good transport: Nanoparticles were prepared by self-assembly of a biodegradable poly(amidoamine), using p24 or ovalbumin as model antigens and CpG as the adjuvant, with the goal of developing therapeutic protein formulations for improved delivery of antigen via the intranasal route. The nanoparticles are nontoxic and stable for at least 10 days at room temperature. Their capacity to pass through epithelial and endothelial cell layers was evaluated in vitro by using a respiratory mucosa-like barrier model.

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