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Dr. Seth A. Jones, Dr. Paul M. Neilsen, Limei Siew, Prof. David F. Callen, Dr. Nathan E. Goldfarb, Prof. Ben M. Dunn and Prof. Andrew D. Abell A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease ChemMedChem 8

Article first published online: 15 OCT 2013 | DOI: 10.1002/cmdc.201300387

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Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.

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