E-mail a Wiley Online Library Link

Dr. Seth A. Jones, Dr. Paul M. Neilsen, Limei Siew, Prof. David F. Callen, Dr. Nathan E. Goldfarb, Prof. Ben M. Dunn and Prof. Andrew D. Abell A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease ChemMedChem 8

Article first published online: 15 OCT 2013 | DOI: 10.1002/cmdc.201300387

Thumbnail image of graphical abstract

Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field