Prof. Christian A. Olsen An Update on Lysine Deacylases Targeting the Expanding “Acylome” ChemMedChem 9
The updated concept! Recently, novel acyl groups have been identified as post-translational modifications to lysine side chains in diverse proteins. Some of these marks appear to be regulated by HDACs and/or sirtuins. Here, these new developments are summarized and discussed with emphasis on the connection to lysine deacylase enzymes including new assays and inhibitors.
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