Erik M. Shapiro, Laura N. Medford-Davis, Tarek M. Fahmy, Cynthia E. Dunbar and Alan P. Koretsky Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI Contrast Media & Molecular Imaging 2
Peripheral T cells were labeled in vitro in whole blood with micron sized iron oxide particles. Specificity was accomplished with anti-CD5antibodies and a biotin/streptavidin bridge. Iron contents as high as 60 pg iron per cell enabled in vitro single cell detection by MRI.
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