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Bianca Waschkau, Andreas Faust, Michael Schäfers and Christoph Bremer Performance of a new fluorescence-labeled MMP inhibitor to image tumor MMP activity in vivo in comparison to an MMP-activatable probe Contrast Media & Molecular Imaging 8

Version of Record online: 29 OCT 2012 | DOI: 10.1002/cmmi.1486

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The fluorescence-labeled low-molecular-weight MMPI Cy5.5-AF489 can be successfully applied to whole-body fluorescence imaging to monitor and quantify MMP activity in xenografted tumors in vivo. In contrast to MMP-mediated activatable fluorescent probes, Cy5.5-AF489 enables a much faster non-invasive detection of MMP activities in tumors. Molecular imaging with the use of this fluorescent probe could aid in providing new opportunities for early detection of tumors and/or metastases, to visualize their expressions and activities and/or their response to therapy.

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