B. Marty, B. Djemaï, C. Robic, M. Port, P. Robert, J. Valette, F. Boumezbeur, D. Le Bihan, F. Lethimonnier and S. Mériaux Hindered diffusion of MRI contrast agents in rat brain extracellular micro-environment assessed by acquisition of dynamic T1 and T2 maps Contrast Media & Molecular Imaging 8
In this study, we present a methodology based on quantitative MRI acquisitions, to precisely assess contrast agent concentration after injection and follow its diffusion in both in vitro and in vivo conditions.
Our results provide accurate data on probe hydrodynamic sizes and tissues tortuosity, as well as an estimation of characteristic diffusion time in rat brain. These findings are valuable information to design molecular probes and calibrate molecular imaging experiments.
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