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Hoe Suk Kim, Lianji Tian, Shunmei Lin, Joo Hee Cha, Hye Seung Jung, Kyong Soo Park and Woo Kyung Moon Magnetic labeling of pancreatic β-cells modulates the glucose- and insulin-induced phosphorylation of ERK1/2 and AKT Contrast Media & Molecular Imaging 8

Version of Record online: 29 OCT 2012 | DOI: 10.1002/cmmi.1490

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SPIO labeling results in an increase in the phosphorylation levels of ERK1/2 and AKT, but the significant decrease in the glucose– and insulin–stimulated phosphorylation of AKT and glucose–stimulated phosphorylation of ERK1/2 and which caused a reduction in the insulin produced upon stimulation with glucose or insulin. SPIO labeling could influence the function of pancreatic β–cells through modulation of the glucose– or insulin–induced activation of ERK1/2 and AKT that leads to insulin biosynthesis.

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