Leonie Rouleau, Romain Berti, Vanessa W. K. Ng, Carl Matteau-Pelletier, Tina Lam, Pierre Saboural, Ashok K. Kakkar, Frédéric Lesage, Eric Rhéaume and Jean-Claude Tardif VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice Contrast Media & Molecular Imaging 8
A photoacoustic molecular probe based on gold nanoshells targeting VCAM-1 in mice was designed and toxicity tests were performed in vitro on cell cultures and in vivo in small animals. The immunonanoshells were assessed for specificity and sensitivity. Photoacoustic tomography capacity to detect gold nanoshells both in phantoms and in vivo was examined. Ex vivo optical projection tomography of hearts and aortas from atherosclerotic and control mice confirmed the selective accumulation of the immunonanoshells in atherosclerotic-prone regions in mice.
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