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Matthias Taupitz, Nicola Stolzenburg, Monika Ebert, Jörg Schnorr, Ralf Hauptmann, Harald Kratz, Bernd Hamm and Susanne Wagner Gadolinium-containing magnetic resonance contrast media: investigation on the possible transchelation of Gd3+ to the glycosaminoglycan heparin Contrast Media & Molecular Imaging 8

Version of Record online: 21 NOV 2012 | DOI: 10.1002/cmmi.1500

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Contrast media based on linear gadolinium complexes showed a relevant increase in T1-relaxivity following 2 h of incubation in heparin solution in the presence of 2.0 mm ZnCl2, indicating transchelation with formation of a macromolecular Gd-heparin complex. Heparin is a glycosaminoglycan (GAG). GAGs are strong chelators and occur in the extracellular matrix. Interaction with GAGs might explain retention of Gd3+ in human tissues, contributing to the development of nephrogenic systemic fibrosis in end-stage renal disease patients.

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