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Tessa Geelen, Leonie E. Paulis, Bram F. Coolen, Klaas Nicolay and Gustav J. Strijkers Passive targeting of lipid-based nanoparticles to mouse cardiac ischemia–reperfusion injury Contrast Media & Molecular Imaging 8

Version of Record online: 21 NOV 2012 | DOI: 10.1002/cmmi.1501

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The accumulation and distribution kinetics of lipid-based micelles and liposomes were studied in a mouse model of myocardial ischemia–reperfusion injury, using MRI and CLSM. Both types of nanoparticles accumulated massively and exclusively in the infarcted myocardium, where more accumulation was observed in acute compared to chronic ischemia–reperfusion injury. Owing to this effective accumulation, paramagnetic and fluorescent, lipid-based micelles and liposomes are promising vehicles for (visualization of) drug delivery in myocardial infarction.

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