Robert Ta, Mojmir Suchy, Joshua H.K. Tam, Alex X. Li, Francisco S. Martinez-Santiesteban, Timothy J. Scholl, Robert H.E. Hudson, Robert Bartha and Stephen H. Pasternak A dual magnetic resonance imaging/fluorescent contrast agent for Cathepsin-D detection Contrast Media & Molecular Imaging 8
An MRI contrast agent has been developed that is targeted to Cathepsin-D. The MR-sensitive portion of the agent was conjugated to a peptide containing a Cathepsin-D cleavage site and a Tat peptide. The Tat peptide promotes transport across the blood–brain barrier, where cleavage/removal by Cathepsin-D traps the agent. The agent was metalated with Gd3+ for T1 contrast or Tm3+ for PARACEST detection. The agent is preferentially taken up by cultured cells over-expressing Cathepsin-D, and retained in the brain of an Alzheimer disease mouse model. This agent could be used to diagnosis Alzheimer disease.
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