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André F. Martins, M. I. M. Prata, S. P. J. Rodrigues, Carlos F. G. C. Geraldes, P. J. Riss, A. Amor-Coarasa, C. Burchardt, C. Kroll and F. Roesch Spectroscopic, radiochemical, and theoretical studies of the Ga3+-N-2-hydroxyethyl piperazine-N′-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga3+- HEPES complexes in 68 Ga labeling reactions Contrast Media & Molecular Imaging 8

Version of Record online: 14 FEB 2013 | DOI: 10.1002/cmmi.1517

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We show by spectroscopic, radiochemical, chromatographic, mass spectrometry and theoretical modelling studies that the HEPES buffer acts as a weakly but competitive chelator of Ga3+. This observation explains its superior performance relative to alternative buffer systems for 67/68Ga radiolabelling in aqueous media.

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