E-mail

E-mail a Wiley Online Library Link

Zhen Ye, Xueming Wu, Mingqian Tan, Jack Jesberger, Mark Grisworld and Zheng-Rong Lu Synthesis and evaluation of a polydisulfide with Gd–DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging Contrast Media & Molecular Imaging 8

Article first published online: 11 JAN 2013 | DOI: 10.1002/cmmi.1520

Thumbnail image of graphical abstract

A polydisulfide containing Gd–DOTA monoamide side chains, GODC, was synthesized and evaluated as a biodegradable macromolecular MRI contrast agent with high kinetic stability. The chelates in the agent were highly stable against transmetallation with Zn2+ ions and the polymer chains were readily reduced by endogenous thiols to facilitate the excretion of the agent. The agent produced strong and prolonged contrast enhancement in the vasculature and tumor periphery of mice bearing breast cancer xenograft.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH