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Zhen Ye, Xueming Wu, Mingqian Tan, Jack Jesberger, Mark Grisworld and Zheng-Rong Lu Synthesis and evaluation of a polydisulfide with Gd–DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging Contrast Media & Molecular Imaging 8

Article first published online: 11 JAN 2013 | DOI: 10.1002/cmmi.1520

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A polydisulfide containing Gd–DOTA monoamide side chains, GODC, was synthesized and evaluated as a biodegradable macromolecular MRI contrast agent with high kinetic stability. The chelates in the agent were highly stable against transmetallation with Zn2+ ions and the polymer chains were readily reduced by endogenous thiols to facilitate the excretion of the agent. The agent produced strong and prolonged contrast enhancement in the vasculature and tumor periphery of mice bearing breast cancer xenograft.

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