Lucas W. E. Starmans, Sander M. J. van Duijnhoven, Raffaella Rossin, Silvio Aime, Mat J. A. P. Daemen, Klaas Nicolay and Holger Grüll SPECT imaging of fibrin using fibrin-binding peptides Contrast Media & Molecular Imaging 8
In this study, we show the potential of a novel 111In-labeled fibrin-binding peptide (FibPep) for noninvasive detection of fibrin deposition using SPECT. FibPep and a negative control peptide (NCFibPep) were synthesized and their fibrin-binding properties were assessed in vitro and in vivo. In vivo SPECT imaging using FibPep allowed clear visualization of thrombi. Ex vivo biodistribution showed significantly increased uptake of FibPep in the thrombus-containing carotid in comparison to the noninjured carotid, whereas nonspecific NCFibPep did not.
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