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Phillip Zhe Sun, Yu Wang, Gang Xiao and Renhua Wu Simultaneous experimental determination of labile proton fraction ratio and exchange rate with irradiation radio frequency power-dependent quantitative CEST MRI analysis Contrast Media & Molecular Imaging 8

Version of Record online: 4 FEB 2013 | DOI: 10.1002/cmmi.1524

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Because the CEST effect varies with the labile proton content, exchange rate and experimental conditions, the commonly used CEST imaging only provides CEST-weighted information. It has been shown with numerical simulation that labile proton fraction ratio and exchange rate can be simultaneously determined by evaluating the radio frequency (RF) power dependence of CEST effect. The quantitative CEST analysis was demonstrated using two CEST phantoms of serially varied pH and CEST agent concentration, which remains promising to augment the conventional CEST-weighted analysis.

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