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Todd K. Stevens, Mark Milne, Adam A. H. Elmehriki, Mojmír Suchý, Robert Bartha and Robert H. E. Hudson A DOTAM-based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity Contrast Media & Molecular Imaging 8

Version of Record online: 4 FEB 2013 | DOI: 10.1002/cmmi.1527

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The Tm3+ chelate of DOTAM [1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane] possessing sterically demanding t-butyl amide substitution favors TSAP geometry. This chelate displays a paraCEST signal associated with the amide proton signal at approximately −100 ppm and thus escapes severe interference associated with macromolecule magnetization transfer. This paraCEST signal also displays high temperature dependence (0.57 ppm °C−1) in the range of 35–42 °C and at neutral pH.

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