E-mail a Wiley Online Library Link

Lisette H. Deddens, Geralda A. F. van Tilborg, Annette van der Toorn, Helga E. de Vries and Rick M. Dijkhuizen PECAM-1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia Contrast Media & Molecular Imaging 8

Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1536

Thumbnail image of graphical abstract

PECAM-1, an endothelial marker that can be used for assessment of post-stroke vascular remodeling, can be effectively targeted in vitro with MPIO conjugated with PECAM-1 antibody, giving rise to significant contrast enhancement on MR images. Nevertheless, application of this targeted contrast agent was ineffective for in vivo molecular MRI of angiogenesis at 3 or 7 days after experimental stroke in mice, which may be explained by inefficient binding of the large multivalent ligand-presenting construct under in vivo conditions.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field